H2N2V1, Main, Exploration, bibRecord, 000E86

Ecological factors driving the long-term evolution of influenza's host range

Identifieur interne : 000E86 ( Main/Exploration ); précédent : 000E85; suivant : 000E87

Ecological factors driving the long-term evolution of influenza's host range

Auteurs : Sarah Cobey [États-Unis] ; Mercedes Pascual [États-Unis] ; Ulf Dieckmann [Autriche]

Source :

Proceedings of the Royal Society B: Biological Sciences [ 0962-8452 ] ; 2010.

RBID : PMC:2981989

Abstract

The evolution of a pathogen's host range is shaped by the ecology of its hosts and by the physiological traits that determine host specificity. For many pathogen traits, there is a trade-off: a phenotype suitable for infecting one set of hosts poorly infects another. Introducing and analysing a simple evo-epidemiological model, here we study how such a trade-off is expected to affect evolution of the host ranges of influenza viruses. We examine a quantitative trait underlying host specificity, given by an influenza virus's degree of adaptation to certain conformations of sialic acid receptors, and investigate how this receptor preference evolves in a minimal network of host species, including humans, that differ in life history and receptor physiology. Using adaptive dynamics theory, we establish thresholds in interspecific transmission rates and host population sizes that govern the emergence and persistence of human-adapted viruses. These ecological thresholds turn out to be largely independent of the strength of the evolutionary trade-off, underscoring the importance of ecological conditions in determining a disease's host range.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981989

DOI: 10.1098/rspb.2010.0519
PubMed: 20444714
PubMed Central: 2981989

Affiliations:

Autriche, États-Unis

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Ecological factors driving the long-term evolution of influenza's host range</title>
<author><name sortKey="Cobey, Sarah" sort="Cobey, Sarah" uniqKey="Cobey S" first="Sarah" last="Cobey">Sarah Cobey</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Department of Ecology and Evolutionary Biology</addr-line>
,<institution>University of Michigan</institution>
,<addr-line>830 North University Avenue, Ann Arbor, MI 48109</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pascual, Mercedes" sort="Pascual, Mercedes" uniqKey="Pascual M" first="Mercedes" last="Pascual">Mercedes Pascual</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Department of Ecology and Evolutionary Biology</addr-line>
,<institution>University of Michigan</institution>
,<addr-line>830 North University Avenue, Ann Arbor, MI 48109</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Howard Hughes Medical Institute</addr-line>
,<institution>University of Michigan, Ann Arbor, MI 48109</institution>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dieckmann, Ulf" sort="Dieckmann, Ulf" uniqKey="Dieckmann U" first="Ulf" last="Dieckmann">Ulf Dieckmann</name>
<affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Evolution and Ecology Program, International Institute for Applied Systems Analysis (IIASA), Schlossplatz 1, 2361 Laxenburg</addr-line>
,<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">20444714</idno>
<idno type="pmc">2981989</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981989</idno>
<idno type="RBID">PMC:2981989</idno>
<idno type="doi">10.1098/rspb.2010.0519</idno>
<date when="2010">2010</date>
<idno type="wicri:Area/Pmc/Corpus">000741</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000741</idno>
<idno type="wicri:Area/Pmc/Curation">000741</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000741</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000952</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000952</idno>
<idno type="wicri:Area/Ncbi/Merge">000528</idno>
<idno type="wicri:Area/Ncbi/Curation">000528</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000528</idno>
<idno type="wicri:doubleKey">0962-8452:2010:Cobey S:ecological:factors:driving</idno>
<idno type="wicri:Area/Main/Merge">000E93</idno>
<idno type="wicri:Area/Main/Curation">000E86</idno>
<idno type="wicri:Area/Main/Exploration">000E86</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Ecological factors driving the long-term evolution of influenza's host range</title>
<author><name sortKey="Cobey, Sarah" sort="Cobey, Sarah" uniqKey="Cobey S" first="Sarah" last="Cobey">Sarah Cobey</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Department of Ecology and Evolutionary Biology</addr-line>
,<institution>University of Michigan</institution>
,<addr-line>830 North University Avenue, Ann Arbor, MI 48109</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pascual, Mercedes" sort="Pascual, Mercedes" uniqKey="Pascual M" first="Mercedes" last="Pascual">Mercedes Pascual</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Department of Ecology and Evolutionary Biology</addr-line>
,<institution>University of Michigan</institution>
,<addr-line>830 North University Avenue, Ann Arbor, MI 48109</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>Howard Hughes Medical Institute</addr-line>
,<institution>University of Michigan, Ann Arbor, MI 48109</institution>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dieckmann, Ulf" sort="Dieckmann, Ulf" uniqKey="Dieckmann U" first="Ulf" last="Dieckmann">Ulf Dieckmann</name>
<affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Evolution and Ecology Program, International Institute for Applied Systems Analysis (IIASA), Schlossplatz 1, 2361 Laxenburg</addr-line>
,<country>Austria</country>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Proceedings of the Royal Society B: Biological Sciences</title>
<idno type="ISSN">0962-8452</idno>
<idno type="eISSN">1471-2954</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>The evolution of a pathogen's host range is shaped by the ecology of its hosts and by the physiological traits that determine host specificity. For many pathogen traits, there is a trade-off: a phenotype suitable for infecting one set of hosts poorly infects another. Introducing and analysing a simple evo-epidemiological model, here we study how such a trade-off is expected to affect evolution of the host ranges of influenza viruses. We examine a quantitative trait underlying host specificity, given by an influenza virus's degree of adaptation to certain conformations of sialic acid receptors, and investigate how this receptor preference evolves in a minimal network of host species, including humans, that differ in life history and receptor physiology. Using adaptive dynamics theory, we establish thresholds in interspecific transmission rates and host population sizes that govern the emergence and persistence of human-adapted viruses. These ecological thresholds turn out to be largely independent of the strength of the evolutionary trade-off, underscoring the importance of ecological conditions in determining a disease's host range.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Autriche</li>
<li>États-Unis</li>
</country>
</list>
<tree><country name="États-Unis"><noRegion><name sortKey="Cobey, Sarah" sort="Cobey, Sarah" uniqKey="Cobey S" first="Sarah" last="Cobey">Sarah Cobey</name>
</noRegion>
<name sortKey="Pascual, Mercedes" sort="Pascual, Mercedes" uniqKey="Pascual M" first="Mercedes" last="Pascual">Mercedes Pascual</name>
<name sortKey="Pascual, Mercedes" sort="Pascual, Mercedes" uniqKey="Pascual M" first="Mercedes" last="Pascual">Mercedes Pascual</name>
</country>
<country name="Autriche"><noRegion><name sortKey="Dieckmann, Ulf" sort="Dieckmann, Ulf" uniqKey="Dieckmann U" first="Ulf" last="Dieckmann">Ulf Dieckmann</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000E86 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000E86 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    H2N2V1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:2981989
   |texte=   Ecological factors driving the long-term evolution of influenza's host range
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:20444714" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a H2N2V1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 14 19:59:40 2020. Site generation: Thu Mar 25 15:38:26 2021

Serveur d'exploration H2N2

Ecological factors driving the long-term evolution of influenza's host range

Ecological factors driving the long-term evolution of influenza's host range

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration H2N2
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.